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Fig. 1 | Molecular Brain

Fig. 1

From: Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease

Fig. 1

Barnes maze performance for 3, 5, and 7 months old WT and A53T mice. (A-C) Latency to escape. In 3-month old mice reduced latency to escape of A53T mice was observed only at day 3 of the training phase (a). In 5-month old A53T mice latency to escape was decreased in both day 3 and 4 of the training phase (b). In 7-month old A53T mice latency to escape was decreased in training phase days 2, 3 and 4 (c). The A53T mice showed reduced time spent in target zone at 5 and 7 months of age compared to WT controls (d). Progressive age-dependent reduction of time spent in target zone was observed in A53T mice (d). (n = 12/group; two-way ANOVA, Sidak; *p < 0.05, **p < 0.01, ***p < 0.005)

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Molecular Brain

ISSN: 1756-6606