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Fig. 2 | Molecular Brain

Fig. 2

From: Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease

Fig. 2

Contextual object recognition test performance for 3, 5, and 7 months old WT and A53T mice. No statistically significant differences were observed in total number of entries in 3, 5 and 7-month old WT and A53T mice (a). No statistically significant differences were observed in total exploration time in 3, 5 and 7-month old WT and A53T mice (b). No statistically significant differences were observed in novel object exploration time in 3, 5 and 7-month old WT and A53T mice (c). Time spend exploring familiar object was increased in 7 mo A53T compared to WT mice (d). Age-dependent effects on familiar object exploration time increase was observed in A53T mice (d). Decrease in discrimination ratio in A53T mice was observed at 5 and 7 months of age compared to WT mice of the same age (e). Age-dependent decrease in discrimination ratio was observed in A53T mice. (3 mo WT/A53T, n = 11/group; 5 mo WT, n = 10/group; 5 mo A53T, n = 11/group; 7 mo WT/A53T, n = 11/group; two-way ANOVA, Sidak; *p < 0.05, ***p < 0.005)

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