Fig. 4

Contextual object recognition test performance for saline and orexin A-treated 5 months old WT and A53T mice. No statistically significant differences were observed in total number of entries between experimental groups (a). No statistically significant differences were observed in total exploration time between experimental groups (b). No statistically significant differences were observed in novel object exploration time between experimental groups (c). Time spend exploring familiar object was increased in WT saline-treated mice compared to WT orexin A-treated (d). Decrease in discrimination ratio was observed in A53T saline-treated mice compared to WT saline-treated mice as well as in A53T orexin A-treated mice compared to WT orexin A-treated mice (e). Orexin A intervention ameliorated increased discrimination ratio in A53T mice (e). Differences in discrimination ratio were observed between WT orexin A-treated mice and A53T saline-treated mice as well. (n = 9/group; one-way ANOVA, Tukey’s; *p < 0.05, **p < 0.01, ***p < 0.005)