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Fig. 5 | Molecular Brain

Fig. 5

From: Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates Hipp-dependent memory impairment in the A53T mice model of Parkinson’s disease

Fig. 5

CNO effects on hippocampus-dependent memory in 5-month old orx-Cre and orx-Cre /A53T mice. No statistically significant differences were observed in total number of entries between experimental groups (a). No statistically significant differences were observed in total exploration time entries between experimental groups (b). No statistically significant differences were observed in novel object exploration time entries between experimental groups (c). No statistically significant differences were observed in familiar object exploration time between orx-Cre cDREADD saline vs orx-Cre cDREADD CNO as well as between orx-Cre/A53T cDREADD saline vs orx-Cre/A53T cDREADD CNO (d). CNO treatment did not affect discrimination ratio in both orx-Cre and orx-Cre/A53T mice. No statistically significant differences were observed in discrimination retio between orx-Cre cDREADD saline vs orx-Cre cDREADD CNO as well as between orx-Cre/A53T cDREADD saline vs orx-Cre/A53T cDREADD CNO (e). (n = 6/group; one-way ANOVA, Tukey’s)

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