Fig. 3
The in vivo effect of MMP7 on Schwann cell proliferation. A and B Representative immunohistochemistry images of the longitude sections of rat sciatic nerve segments treated with A saline control and B MMP7 recombinant protein. Rat sciatic nerve segments were collected at 1, 7 and 14 days after nerve crush. Green indicated S100 staining of Schwann cells, red indicated Ki67 staining of proliferating cells, and blue indicated Hoechst staining of cell nuclei. Arrows indicated proliferating Schwann cells. Scale bars represented 50 μm. Boxed areas in (A and B) were demonstrated in higher magnifications in (A’ and B′), respectively. Arrows indicated proliferating Schwann cells too. Scale bars represented 20 μm. c Histogram of proliferation ratio in rats injected with saline or MMP7 recombinant protein at 1, 7 and 14 days after nerve crush, n = 3