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Fig. 5 | Molecular Brain

Fig. 5

From: Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury

Fig. 5

The in vivo effect of MMP7 on axon and myelin sheath regeneration. a and b Representative immunohistochemistry images of the cross sections of rat sciatic nerve segments (crush sites) treated with saline at (a) 7 days and (b) 14 days after nerve crush. Red indicated S100 staining of Schwann cells and green indicated NF staining of axons. Scale bars represented 20 μm. c and d Representative immunohistochemistry images of rat sciatic nerve segments (crush sites) treated with MMP7 recombinant protein at (c) 7 days and (d) 14 days after nerve crush. Red indicated S100 staining of Schwann cells and green indicated NF staining of axons. Scale bars represented 20 μm. e Summarized numbers of axons in rats injected with saline or MMP7 recombinant protein. f Summarized numbers of myelin sheaths in rats injected with saline or MMP7 recombinant protein. g Summarized ratio of myelinated axons in rats injected with saline or MMP7 recombinant protein. Asterisk indicated significant different from saline control, * p-value < 0.05, n = 3

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