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Fig. 10 | Molecular Brain

Fig. 10

From: Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1

Fig. 10

Silence Notch1 aggravated the severity of epileptic brain damage. a Rats (N = 8 in each group) were injected intracerebroventricularly with siRNA negative control (siRNA NC) or siRNA targeting Notch1 (siRNA Notch1) for three days and relative Notch1 expression was assessed by qRT-PCR to detect the siRNA efficiency against Notch1. After transfection of 3 days, the levels of SOD (b), MDA (c), IL-1β (d), IL-6 (e) and IL-18 (f) were detected. *P < 0.05 vs. siNC group. Photomicrographs of apoptotic cells in CA1 region (g) and (h) CA3 region (arrows indicate the positive cells, bar = 100 μm, magnification × 400)

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Molecular Brain

ISSN: 1756-6606