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Fig. 9 | Molecular Brain

Fig. 9

From: Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1

Fig. 9

The interaction between Notch-1 and microRNA-146a (miRNA-146a). a a binding site of miRNA-146a at 3′-UTR of Notch-1 predicted by Target Scan; b) the relative fluorescence unit of co-transfected cells detected by dual luciferase reporter gene (DLR) assay. *, P < 0.05 vs. Notch-1-WT + miRNA-146a inhibitor. c Spearman’s rank correlation analysis was used to detect the correlation between Notch1 and miRNA-146a expression. d The expression of miRNA-146a transfected with miRNA-146a mimics or miRNA-146a mimics NC in the hippocampus of rats was detected by qRT-PCR. e Western blot analysis was used to detect the expression of Notch1 protein after transfected with miRNA-146a mimics or miRNA-146a mimics NC in the hippocampus of rats. *, P < 0.05 vs. miRNA-146a mimics NC

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Molecular Brain

ISSN: 1756-6606