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Table 1 Summary of brain zinc transporters and their alterations in the progression of AD

From: Zinc transporters in Alzheimer’s disease

Gene name

Alias

Tissue/ Subcellular localization

Neurological disease

Expression levels in the progression of AD

SLC30A1

ZnT1

Dendritic spines, synaptic membranes [12]

Alzheimer’s Disease [53]

Decreased in PCAD, increased in both EAD and LAD [20, 53]

SLC30A3

ZnT3

Hippocampus, cortex [54]

Alzheimer’s Disease [19], Learning deficit and memory loss [18]

Decreased [19]

SLC30A4

ZnT4

Endosomal/secretory vesicles [53]

Alzheimer’s Disease [55]

Increased [55]

SLC30A5

ZnT5

Golgi apparatus [48]

Alzheimer’s Disease [56]

Unknown

SLC30A6

ZnT6

Golgi apparatus [48]

Alzheimer’s Disease [53, 57]

Increased [53, 55]

SLC30A7

ZnT7

Golgi apparatus [58]

Alzheimer’s Disease [56]

Increased [59]

SLC30A10

ZnT10

Brain and liver [14]

Parkinson’s Disease [49]

Alzheimer’s Disease [60]

Decreased [60]

SLC39A1

ZIP1

Hippocampus, thalamus [15]

Alzheimer’s Disease [61]

Increased [61]

SLC39A3

ZIP3

Hippocampus pyramidal neurons [62]

Seizure-induced CA1degeneration [62]

Unknown

SLC39A4

ZIP4

Choroid plexus [15]

Glioma [63]

Unknown

SLC39A6

ZIP6

Hippocampal pyramidal apical membrane of choroid plexus [17]

Unknown

Unknown

SLC39A9

ZIP9

Trans-Golgi network [64]

Unknown

Unknown

SLC29A13

ZIP13

Golgi apparatus [14]

SCD-EDS [65]

Unknown