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Fig. 2 | Molecular Brain

Fig. 2

From: Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse

Fig. 2

Activity-dependent redistribution of two cohorts of mEPSCs with distinct decay kinetics. a Representative mEPSC traces (top panel) from naive and TBS synapses are scaled and overlaid to show their variable decay time courses fit with a double exponential function (bottom panel). b τfast values from individual mEPSCs are plotted on conventional histograms with the total area under the curve being normalized to 1 and then fit with a double component Gaussian function to yield the relative weight of the fast (A0.4) and slow (A0.8) decay cohorts for naïve (left panel) and TBS synapses (right panel). c Comparison of naive and TBS treated synapses (pooled from all synapses in each group) exemplifies a decrease in the relative weight of the slow population (A0.8) and increase in the weight of the fast population (A0.4) following TBS. d The relative weights of the A0.4 and A0.8 cohorts from TBS and LFS treated synapses compared to their associated naive controls. e-f Averaged mEPSC amplitudes and frequency of TBS and LFS treated synapses with their associated naive controls. g Comparison of naïve synapses which spent varying amounts of time in recording solution

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