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Fig. 4 | Molecular Brain

Fig. 4

From: Delayed expression of activity-dependent gating switch in synaptic AMPARs at a central synapse

Fig. 4

The gating switch of synaptic AMPARs can be pharmacologically recapitulated. a The same experimental paradigm except that TBS is replaced by a 2 min co-application of 100 μM NMDA + 100 μM DHPG, which evokes bursts of action potentials (30–70 Hz, 30–60 ms bursts, every 0.5–1 s). b Examples of raw mEPSCs (top panels) are scaled and superimposed with accompanying curve fits (middle panels) for naĂ¯ve (left column) and drug treated synapses (right column). The averaged mEPSCs are contrasted to show acceleration in the time course of mEPSCs after co-activation of NMDARs and Group 1 mGluRs after a 45 min non-invasive expression phase. c. Summary plots showing an increase in the size of A0.4 component of mEPSCs without affecting mEPSC amplitudes after co-activation of NMDARs and mGluRs. d Blocking action potentials with 1 μM TTX during co-application of the agonists prevents the increase in the relative weight of A0.4 component

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