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Fig. 1 | Molecular Brain

Fig. 1

From: Cell-specific expression of Epac2 in the subventricular and subgranular zones

Fig. 1

Colocalization of Epac2-immunopositive signals with NSCs, migrating neuroblasts, or ependymal cells in the V-SVZ of adult mice; and with NSCs, TAPs, or immature neurons in the SGZ. a. Overview of the V-SVZ and SGZ. Left panel, sagittal section through a mouse brain. Middle panel, cellular composition of the V-SVZ. A, type A cell; B, type B cell; C, type C cell; E, type E cell. Right panel, cellular composition of the SGZ. 1, type 1 cell (NSCs); 2, type 2 cell; 3, type 3 cell; imN, immature neurons. b-d. Representative immunofluorescence images of the V-SVZ. Epac2-immunoreactive signals are observed in the GFAP-positive NSCs (b, green boxes), DCX-positive neuroblasts (c, pink boxes), and beta-catenin-positive ependymal cells (d, yellow boxes). The white box shown in “c” indicates a neuroblast showing non-colocalization. e-f. Representative immunofluorescence images of the SGZ. GFAP-positive radial glia-like stem cells (e, green box), DCX-positive TAPs (f, pink boxes), and a DCX-positive immature neuron with one strong branching (f, yellow box) express Epac2 protein. Scale bars, 25 μm. g. Colocalization rates of Epac2-immunopositive cells with each of the cell marker protein-positive cells in the V-SVZ. H. Colocalization rates of Epac2-immunopositive cells with each type of cell marker protein-positive cell in the SGZ. g and h, Values in tables are presented as mean ± SEM.; n = cell numbers (See Materials and Methods)

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