Fig. 2

Effects of TNF-α exposure on sodium current amplitude in DRG neurons Representative trace of the total sodium current recorded from cells with and without exposure to TNFα (a), along with their normalized current density-voltage relations (b). c Peak current density values for the total sodium current with and without exposure to TNF-α. d, e, f same as in panels a-c but for the TTXs sodium current component. g, h, i same as in panels a-c but for the TTXr sodium current component. For panels c, f and i, peak currents were measured at − 5 mV. * Total sodium current vs total sodium current after exposure to TNF-α, # TTXs sodium current vs TTXs sodium current after exposure to TNF, § TTXr sodium current vs TTXr sodium current after TNF exposure - p < 0.05; One Way ANOVA test followed by Bonferroni. For panels b, e and h, * Total sodium current vs total sodium current after exposure to TNF-α, # TTXs sodium current vs TTXs sodium current after exposure to TNF, § TTXr sodium current vs TTXr sodium current after TNF exposure - p < 0.05; Two Way ANOVA test followed by Bonferroni