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Table 4 Comparison of the peak current density values (pA/pF) at a test potential of − 5 mV between the INa Total, INa TTXs and Ina TTXr with and without TNF-α

From: TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

 

INa Total

INa TTXs

INa TTXr

 

Control

− 134.7 ± 30.3 n = 8

−89.7 ± 21.9 n = 5

− 58.2 ± 8.4 n = 8

 

+ TNF

− 227.9 ± 29.2* n = 14

− 177.0 ± 29.8* n = 11

−95.9 ± 14.7* n = 12

 

p value

< 0.001

0.0027

0.0044

 
  1. *Significant by One Way ANOVA test, followed by Bonferroni (control vs TNF)
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Molecular Brain

ISSN: 1756-6606