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Table 6 Comparison of the V50 and Vh values (mV) for steady state activation and steady state inactivation curves with and without TNF-α

From: TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

 

V1/2

Vh

INa Total

INa TTXs

INa TTXr

INa Total

INa TTXs

INa TTXr

Control

−7.7 ± 0.5 n = 8

−9.9 ± 0.6 n = 6

− 9.6 ± 0.6 n = 8

−19.7 ± 0.2 n = 7

−20.8 ± 0.3 n = 6

−18.3 ± 0.2 n = 6

+ TNF

−12.9 ± 0.2* n = 14

−15.3 ± 0.3* n = 11

−10.7 ± 0.9 n = 15

−23.0 ± 0.4* n = 6

−23.1 ± 0.5* n = 4

− 19.6 ± 0.5 n = 4

p value

< 0.001

< 0.001

0.2589

< 0.001

0.0052

0.4003

  1. *Significant by One Way ANOVA test, followed by Bonferroni (control vs TNF)