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Table 7 Comparison of peak current density (pA/pF), at a test potential of − 5 mV, recorded from Control cells and cells expressing various CRMP2 constructs with and without exposure to TNF-α

From: TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation

Control

CRMP2 WT

CRMP2-K374A

CRMP2 WT + TNF-α

CRMP2-K374A + TNF-α

p value

−93.6 ± 19.6 n = 15

− 89.4 ± 9.2 n = 17

0.6722

−93.6 ± 19.6 n = 16

− 49.2 ± 5.2* n = 19

< 0.001

−93.6 ± 19.6 n = 17

− 137.6 ± 18.9* n = 15

< 0.001

−93.6 ± 19.6 n = 18

− 76.0 ± 9.8 n = 11

0.1420

− 89.4 ± 9.2 n = 17

−49.2 ± 5.2* n = 19

< 0.001

− 89.4 ± 9.2 n = 17

− 137.6 ± 18.9* n = 15

< 0.001

− 89.4 ± 9.2 n = 17

− 76.0 ± 9.8 n = 11

0.2566

− 49.2 ± 5.2 n = 19

−137.6 ± 18.9* n = 15

< 0.001

−49.2 ± 5.2 n = 19

− 76.0 ± 9.8 n = 11

0.0245

− 137.6 ± 18.9 n = 15

−76.0 ± 9.8* n = 11

< 0.001

  1. *, p < 0.05; One Way ANOVA test followed by Bonferroni
  2. (−) indicates that the respective group is not part of the comparison on that row