Fig. 1From: Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO miceIncreased baseline Fabp7 mRNA expression, and disruption of its circadian rhythm, in Bmal1 KO. (a) Average expression of hypothalamic Fabp7 mRNA is ~7fold greater in BMAL KO compared to WT mice, while Fabp3 mRNA and Fabp5 mRNA are stable (n = 18 per group). ***p < 0.001 Fabp7 mRNA KO/WT vs. Fabp3 mRNA or Fabp5 mRNA KO/WT (t-test). (b) Normalized mRNA expression values (to mean of circadian values within each group) of various Fabps depicts the circadian oscillation of Fabp7 mRNA in C57BL/6 WT which is absent in BMAL KO mice (n = 3 per group per timepoint). Fabp7 mRNA shows a significant circadian dependent change in expression based on genotype. Two-way ANOVA (p < 0.001). ***p < 0.001, **p < 0.01, *p < 0.05 vs ZT0 (post-hoc Bonferroni), while there is no significant difference for circadian variation of Fabp7 mRNA in BMAL KO miceBack to article page