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Fig. 1 | Molecular Brain

Fig. 1

From: Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice

Fig. 1

Increased baseline Fabp7 mRNA expression, and disruption of its circadian rhythm, in Bmal1 KO. (a) Average expression of hypothalamic Fabp7 mRNA is ~7fold greater in BMAL KO compared to WT mice, while Fabp3 mRNA and Fabp5 mRNA are stable (n = 18 per group). ***p < 0.001 Fabp7 mRNA KO/WT vs. Fabp3 mRNA or Fabp5 mRNA KO/WT (t-test). (b) Normalized mRNA expression values (to mean of circadian values within each group) of various Fabps depicts the circadian oscillation of Fabp7 mRNA in C57BL/6 WT which is absent in BMAL KO mice (n = 3 per group per timepoint). Fabp7 mRNA shows a significant circadian dependent change in expression based on genotype. Two-way ANOVA (p < 0.001). ***p < 0.001, **p < 0.01, *p < 0.05 vs ZT0 (post-hoc Bonferroni), while there is no significant difference for circadian variation of Fabp7 mRNA in BMAL KO mice

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