Fig. 3

Sinomenine inhibits oligomeric amyloid beta-induced production of inflammation-related molecules in the astrocytic cells. The C8D1A astrocytic cells were treated with oligomeric amyloid beta (ADDL) in the absence or presence of sinomenine. The levels of inflammation-related molecules were assessed using cytometric bead array inflammation kit. Significant increase in the inflammation-related molecules was observed in the cells exposed to ADDL. However, sinomenine inhibited ADDL-induced increase in the levels of these molecules (IL-12p70, IL-6, IFN-γ, IL-10, MCP-1, n = 7; TNF, n = 5, in all groups). Sinomenine alone did not affect the levels of these molecules. Asterisks denote significant difference from control (p < 0.05). # indicates significant difference (p < 0.05) between groups as indicated