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Fig. 3 | Molecular Brain

Fig. 3

From: A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity

Fig. 3

Expression of Cav3.2 P1210L and ΔI153 variants. a Representative immunoblot of Cav3.2 from tsA-201 cells expressing wild-type (WT), P1210L, and ΔI153 channel variants. b Corresponding mean expression levels of P1210L and ΔI153 variants relative to WT channels. c Representative charge movement traces recorded at the ionic reversal potential from cells expressing wild-type (WT, black trace), P1210L (blue trace), and ΔI153 (red trace) channel variants. The dotted line depicts the time course of the integral for each trace. d Corresponding mean Qmax values calculated for each investigated cell. e Corresponding mean Gmax/Qmax ratios. f Corresponding mean 10–90% rise times calculated from the integral time course shown in panel c

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