Fig. 3
CGRP1 receptor was involved in the potentiation induced by CGRP. The peptide CGRP1 receptor antagonist CGRP8–37 (1 μM) (a) and non-peptide CGRP1 receptor antagonist BIBN 4096 (1 μM) (b) were applied during the baseline and added CGRP periods. Top: sample traces showed the amplitude of the baseline, application of CGRP (10 nM) and washout period for CGRP8–37 (1 μM) (a) and BIBN 4096 (1 μM) (b). Middle: a time line plot of one representative sample for CGRP8–37 (1 μM) (a) and BIBN 4096 (1 μM) (b). Bottom: Pooled data showed no differences among baseline, applied CGRP and washout periods for CGRP8–37 (1 μM, n = 7 neurons/5 mice) (a) and BIBN 4096 (1 μM, n = 8 neurons/4 mice) (b)