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Fig. 3 | Molecular Brain

Fig. 3

From: Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice

Fig. 3

CGRP1 receptor was involved in the potentiation induced by CGRP. The peptide CGRP1 receptor antagonist CGRP8–37 (1 μM) (a) and non-peptide CGRP1 receptor antagonist BIBN 4096 (1 μM) (b) were applied during the baseline and added CGRP periods. Top: sample traces showed the amplitude of the baseline, application of CGRP (10 nM) and washout period for CGRP8–37 (1 μM) (a) and BIBN 4096 (1 μM) (b). Middle: a time line plot of one representative sample for CGRP8–37 (1 μM) (a) and BIBN 4096 (1 μM) (b). Bottom: Pooled data showed no differences among baseline, applied CGRP and washout periods for CGRP8–37 (1 μM, n = 7 neurons/5 mice) (a) and BIBN 4096 (1 μM, n = 8 neurons/4 mice) (b)

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