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Fig. 7 | Molecular Brain

Fig. 7

From: Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice

Fig. 7

AC1-PKA signal pathways were involved in the CGRP induced potentiation. a Selective AC1 inhibitor, NB001 (50 μM) attenuated the effect of CGRP (10 nM) in the IC. Top: sample traces showed the amplitude of the baseline, application of CGRP (10 nM) and washout period for NB001 (50 μM). Middle: representative sample of EPSCs did not significantly change before and after added CGRP. Bottom: The averaged data did not show significant differences after applying CGRP (n = 7 neurons/5 mice). b PKA inhibitor, KT5720 (1 μM) inhibited the effect of CGRP (10 nM) in the IC. Top: Original traces showed the amplitude of the baseline, application of CGRP (10 nM) and washout period for KT5720 (1 μM). Middle: representative sample of EPSCs failed to show significant changes before and after added CGRP. Bottom: The averaged data did not find significant differences after applying CGRP (n = 7 neurons/4 mice)

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