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Fig. 8 | Molecular Brain

Fig. 8

From: Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice

Fig. 8

The proposed model for signaling pathways of CGRP induced potentiation. Left: a simplified diagram showed that the PBN is the prominent location of CGRP- expressing neurons in the CNS, which projects to the IC and other regions. Right: a synaptic model for the CGRP induced potentiation in the IC. CGRP likely causes the potentiation by enhancing presynaptic release of glutamate, although we cannot completely rule out the possibility of postsynaptic action. The calcium-stimulated AC1 is critical for CGRP induced potentiation and downstream protein kinase PKA is also required

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