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Fig. 2 | Molecular Brain

Fig. 2

From: BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses

Fig. 2

Long-term BDNF exposure impacts neuronal survival and excitatory synapses. In (a) Immunofluorescence images showing neuronal and glial cells in Control (left) and BDNF (right) conditions (anti-β-tubulin III, in red; anti-GFAP, in green; in all, nuclei are visualized by DAPI in blue). In (b) the plots summarize neuronal densities and pyramidal cells density on Control (in grey) and after BDNF exposure (in blue) compared to cellular densities before any treatment (in green); striped bars refer to all neuronal cells while plain bars refer to pyramidal ones. In (c) sample tracings of mEPSCs recorded in Control (black trace) and BDNF (blue trace) treated cultures. In (d) cumulative distribution of mEPSCs amplitude values of Control (grey) and BDNF (blue) EPSCs (Kolmogorov-Smirnov test; P < 0.001). In (e) bar plots reporting mEPSC frequency values. BDNF treatment significantly increased the frequency of mEPSCs (P < 0.001, one-way ANOVA)

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Molecular Brain

ISSN: 1756-6606