Fig. 3
From: Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
Noradrenaline induced inward current in pyramidal cells via α1 receptor. a Samples showing High dose (50 μM) but not low dose (10 μM) of NA produced inward currents. b Samples showing α1 receptors antagonist prazosin, but not α2 receptors antagonist yohimbine nor β1 receptors antagonist propranolol blocked the inward current induced by NA (50 μM). C, Averaged results showing high dose but not low dose of NA induced inward current (10 μM NA: n = 13, 50 μM NA: n = 12, 100 μM NA: n = 12). The inward currents were blocked by α1 receptors antagonist, but not α2 receptors nor β receptors antagonist. High dose of NA (50 μM) produced inward current is blocked by Prazosin (10 μM NA: 0.34 ± 3.74 pA, n = 13; 50 μM NA: 23.73 ± 4.13 pA, n = 12; 100 μM NA: 15.69 pA ± 3.82 pA, n = 12; Prazosin:: − 5.94 ± 3.76 pA, n = 9; Yohimbine: 20.58 ± 4.59 pA, n = 8; Propranolol: 16.35 ± 4.79 pA, n = 8). *P < 0.05, 10 μM NA vs. 50 μM or 100 μM NA, Prazosin vs. Yohimbine or Propranolol. One-Way ANOVA