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Fig. 2 | Molecular Brain

Fig. 2

From: Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice

Fig. 2

CBD3 counteracts the cognitive decline in APP/PS1 mice in Morris water maze test. a The escape latency (in minutes) of the WT or APP/PS1 mice treated with nothing, with AAV carrying NT4-TAT or AAV carrying NT4-TAT-CBD3 in the spatial learning test (n = 6). b The percentage of time spent in the target quadrant in the probe test (n = 6). c The number of crossings through the target quadrant (where the platform was previously located) in the probe test (n = 6). d Representative path tracings in each quadrant. The green circle represents the submerged platform. *P < 0.05, one-way ANOVA with Dunnett’s post-hoc test

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