Fig. 3

CBD3 expression reduces Aβ1–42 and p-tau plaques. Representative micrographs of hippocampal sections stained with Aβ1–42 (a), phosphorylated-tau (p-tau) (b) and total-tau (t-tau) (c). The hippocampal sections are from wildtype (WT) mice, APP/PS1 mice, APP/PS1 mice administered control AAV, or APP/PS1 mice administered CBD3 harboring AAV. Sections were from 3 to 4 months old mice and taken 9 days after administration of the virus nasally. Representative of n = 3 for age-matched control and n = 3 for the APP/PS1 mice. *P < 0.05, one-way ANOVA with Dunnett’s post-hoc test. n.s., not significant