Fig. 5

Apoptosis within the hippocampus of AD brains. a Representative grayscale images of TUNEL staining of CA1–2 transitional field of age-matched wildtype (WT) or APP/PS1 mice brains. The hippocampal sections are from wildtype (WT) mice, APP/PS1 mice, APP/PS1 mice administered control AAV, or APP/PS1 mice administered CBD3 harboring AAV. b Quantification of the percent of apoptotic cells in the indicated conditions. CBD3 overexpression reduced neuron apoptosis in APP/PS1 transgenic mice. The number of TUNEL-positive cells counted in CBD3 group was significantly lower than those in model and vector groups. Representative of n = 3 for age-matched control and n = 3 for the APP/PS1 mice. *P < 0.05, one-way ANOVA with Dunnett’s post-hoc test. n.s., not significant