Fig. 2
From: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Conditional deletion of DCC from CA1 or CA3 pyramidal neurons impairs novel object place recognition. a Schematic representation of the novel object place recognition task. b-d R4ag11-Cre/DCCfl/fl mice did not show significant differences in the total exploration time for either object (b; R4ag11-Cre/DCCfl/fl: n = 7, 21.4 ± 1.7 s,, Control: n = 9, 18.7 ± 2.5 s; p = 0.42), but spent significantly less time with the displaced object (c; R4ag11-Cre/DCCfl/fl: n = 7, − 1.0 ± 2.8 s,, Control: n = 9, 6.5 ± 1.2 s; t14 = 2.74, p = 0.016) and showed reduced investigation ratio (d; R4ag11-Cre/DCCfl/fl: n = 7, 0.47 ± 0.08, Control: n = 9, 0.69 ± 0.04; t14 = 2.69, p = 0.017). e-g Conditional deletion of DCC from CA3 pyramidal neurons resulted in no differences in total exploration time (E; Grik4-Cre/DCCfl/fl: n = 5, 18.3 ± 4.5 s, Control: n = 8, 16.2 ± 1.1 s, p = 0.59) compared to control mice (black), but significantly less time was spent with the displaced object (f; Grik4-Cre/DCCfl/fl: n = 5, − 2.3 ± 1.6 s, Control: n = 8, 6.4 ± 1.4 s; t11 = 3.93, p = 0.002) and the investigation ratio was significantly reduced (G; Grik4-Cre/DCCfl/fl: n = 5, 0.46 ± 0.03, Control: n = 8, 0.71 ± 0.05; t11 = 3.66, p = 0.003). * denotes p < 0.05, ** denotes p < 0.01