Fig. 3
From: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Conditional deletion of DCC from CA1 or CA3 pyramidal neurons does not impair performance of novel object recognition task. a Schematic representation of the novel object recognition task. b-d R4ag11-Cre/DCCfl/fl (red) show no significant differences in total exploration time (b; R4ag11-Cre/DCCfl/fl: n = 14, 22.1 ± 3.0 s, Control: n = 14, 27.6 ± 3.7 s; p = 0.26), time spent with novel object (c; R4ag11-Cre/DCCfl/fl: n = 14, 5.2 ± 1.6 s, Control: n = 14, 5.8 ± 2.3 s; p = 0.83), or investigation ratio (d; R4ag11-Cre/DCCfl/fl: n = 14, 0.63 ± 0.4, Control: n = 14, 0.60 ± 0.03 s; p = 0.52) compared to control littermates (black). e-g Grik4-Cre/DCCfl/fl did not spend more total time exploring objects (e; Grik4-Cre/DCCfl/fl: n = 6, 30.88 ± 8.851 s, Control: n = 8, 28.7 ± 4.9 s, p = 0.82), time spent with novel object (f; Grik4-Cre/DCCfl/fl: n = 6, 16.2 ± 4.6 s, Control: n = 8, 15.5 ± 3.0 s, p = 0.89), or investigation ratio (g; Grik4-Cre/DCCfl/fl: n = 6, 0.78 ± 0.02, Control: n = 8, 0.78 ± 0.02 s, p = 0.99)