Fig. 4
From: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Intrinsic excitability of CA1 pyramidal neurons in R4ag11-Cre/DCCfl/fl and Grik4-Cre/DCCfl/fl mice. a Membrane potential responses to hyperpolarizing and depolarizing current pulses in CA1 pyramidal neurons derived from age-matched control (black, left) and R4ag11-Cre/DCCfl/fl (CA1 cKO; red, right). b-c Group data showing resting membrane potential (b; R4ag11-Cre/DCCfl/fl: − 56.6 ± 1.5 mV, Control: − 61.1 ± 1.1 mV, t25 = 2.39, p = 0.024) and input resistance (c; R4ag11-Cre/DCCfl/fl: 116 ± 8 MΩ, Control: 123 ± 10 MΩ, p = 0.602) for CA1 pyramidal neurons from R4ag11-Cre/DCCfl/fl and control mice. d Membrane potential traces in response to hyperpolarizing and depolarizing current pulses in CA1 pyramidal neurons from control (black, left) and Grik4-Cre/DCCfl/fl (CA3 cKO; green, right). e-f Group data show no significant differences in input resistance (e; Grik4-Cre/DCCfl/fl: 119 ± 10 MΩ, Control: 106 ± 7 MΩ, p = 0.325) or resting membrane potential (f; Grik4-Cre/DCCfl/fl: − 61.3 ± 0.7 mV, Control: − 62.2 ± 1.6 mV, p = 0.62) between Grik4-Cre/DCCfl/fl mice and control littermates. * denote p < 0.05