Fig. 7
From: Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus
Conditional deletion of DCC from CA1 pyramidal neurons decreases sEPSC amplitude. a Representative spontaneous excitatory postsynaptic current (sEPSC) traces in CA1 pyramidal neurons from control (black, top) and R4ag11-Cre/DCCfl/fl (CA1 cKO; red, bottom) hippocampal slices. b-c Cumulative distribution plots (left) and group data (right) show a significant decrease in the average amplitude of sEPSCs in R4ag11-Cre/DCCfl/fl mice (b; R4ag11-Cre/DCCfl/fl: n = 15, 13.2 ± 0.5 pA, Control: n = 8, 15.6 ± 1.0 pA; t21 = 2.26, p = 0.034) but no change in average frequency (c; R4ag11-Cre/DCCfl/fl: n = 15, 2.3 ± 0.4 Hz, Control: n = 8, 2.7 ± 0.3 Hz; p = 0.59). d Representative sEPSC traces from CA1 pyramidal neurons from control (black, top) and Grik4-Cre/DCCfl/fl mice (CA3 cKO; green, bottom). e-f Cumulative distribution plots (left) and group data (right) show no changes in average sEPSC amplitude (e; Grik4-Cre/DCCfl/fl: n = 8, 13.3 ± 0.6 pA, Control: n = 7, 14.3 ± 1.7 pA; p = 0.60) or average frequency (f; Grik4-Cre/DCCfl/fl: n = 8, 2.6 ± 0.5 Hz, Control: n = 7, 2.6 ± 0.5 Hz; p = 0.982) between Grik4-Cre/DCCfl/fl and control littermates. K-S test for cumulative distribution plots. * denotes p < 0.05