Fig. 7
From: Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling
Schematic representation of site-specific regulation of TRPM8 by MOR-PKCβ signaling. Sustained morphine treatment acting on MOR induces PLC activation (1) which regulates PKCβ activity (2). The activated PKCβ phosphorylates the C terminus domain of the TRPM8 channel at S1040 and S1041 (3). This leads to a reduction of activity-induced channel desensitization (4). Both, increase in excitability of TRPM8-expressing neurons and reduction in activity-induced desensitization promotes morphine-induced cold hypersensitivity that is associated with chronic opioid treatment