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Fig. 5 | Molecular Brain

Fig. 5

From: PDK1 regulates the survival of the developing cortical interneurons

Fig. 5

The loss of Pdk1 resulted in increased cell apoptosis. (a-b) Immunofluorescence showing that the number of Caspase-3+ cells was no differences in the subpallium of Pdk1 cKO and control mice at E12.5. (c-d’) The number of Caspase-3+ cells was significantly increased in the Pdk1 cKO subpallium compared with control at E14.5. (e-f) Increased number of Caspase-3+ cells in the Pdk1 cKO subpallium compared to control at E16.5. (g-h) Immunofluorescence for Caspase-3 showed that the number of Caspase-3+ cells was increased in the cortex of Pdk1 cKO mice compared with control mice at P6. (i) Statistical analysis of Caspase-3+ cells (E12.5 Pdk1 cKO: N = 3; Ctrl: N = 3; P = 0.9231; E14.5 Pdk1 cKO: N = 3; Ctrl: N = 3; P = 0.0048; E16.5 Pdk1 cKO: N = 3; Ctrl: N = 3; P = 0.0114; P6 Pdk1 cKO: N = 3; Ctrl: N = 3; P = 0.00004, Multiple t-test, with alpha = 0.05/4 = 0.0125). The data are presented as the mean ± SEM. Scale bar, 100 μm

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