Fig. 3
From: Frequency-dependent gating of feedforward inhibition in thalamofrontal synapses
Feedforward inhibitory postsynaptic currents (IPSCs) depress faster than excitatory postsynaptic currents (EPSCs). a Sample traces of an EPSC and IPSC in dorsal anterior cingulate cortex (dACC) L2/3 pyramidal neurons. b−c Normalized amplitudes of an EPSC and IPSC at 5 Hz (b) and 10 Hz (c) (7 and 5 cells were recorded for the EPSC and IPSC, respectively; 5 Hz Pstim2 = 0.35, Pstim3 = 0.28, Pstim4 = 0.073, *Pstim5 = 0.047, unpaired t-test, parametric; 10 Hz Pstim2 = 0.17, Pstim3 = 0.10, *Pstim4 = 0.050, *Pstim5 = 0.032, unpaired t-test, parametric). d−e Onset latencies of EPSC and IPSC after consecutive stimulations at d 5 Hz and e 10 Hz (17 and 8 cells were recorded for the EPSC and IPSC, respectively; EPSC 5 Hz, Pstim2 = 0.080, *Pstim3 = 0.013, ****Pstim4 < 0.0001, **Pstim5 = 0.0011, unpaired t-test, parametric; EPSC 10 Hz, *Pstim2 = 0.40, ***Pstim3 = 0.0008, **Pstim4 = 0.0038, **Pstim5 = 0.0082, unpaired t-test, parametric; IPSC 5 Hz, ***Pstim2 = 0.0007, ***Pstim3 = 0.0002, ****Pstim4 < 0.0001, ***Pstim5 = 0.0007, unpaired t-test, parametric; IPSC 10 Hz, *Pstim2 = 0.015, ****Pstim3 < 0.0001, ****Pstim4 < 0.0001, ***Pstim5 = 0.0001, unpaired t-test, parametric; P value between EPSC and IPSC groups, 5 Hz, #Pstim2 = 0.013, #Pstim3 = 0.017, Pstim4 = 0.13, #Pstim5 = 0.020, unpaired t-test, parametric; P value between EPSC and IPSC groups, 10 Hz, Pstim2 = 0.26, ##Pstim3 = 0.0038, Pstim4 = 0.069, ##Pstim5 = 0.0044, unpaired t-test, parametric)