Fig. 4
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Pearson correlation heatmap and average linkage hierarchical cluster analysis of the row Z-scores obtained from our RNA-seq dataset from genes associated with the MGnD microglia phenotype. The gene designations are to the right of the heatmap. Genes in black are decreased in the MGnD microglia. Genes in red are increased in MGnD microglia. The mouse groups are color coded (refer to key on the figure) for ease of comparison. A core cluster representing a mix of 51 genes that are typically increased or decreased in MGnD microglia, which display a coordinated pattern of expression during prion disease, are indicated with red distance lines to the left of the dendrogram. An asterisk next to the gene name indicates these genes are significantly different in our RNA-seq analysis for prion-infected mice relative to mock-infected mice