From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Gene | Description | 80 dpia | 100 dpi | ~ 157c dpi | |||
---|---|---|---|---|---|---|---|
FCb | P value | FC | P value | FC | P value | ||
Pan | |||||||
Aspg | Asparaginase | 1.1 | 4.7 × 10− 2 | 1.4 | 7.2 × 10− 4 | 3.1 | 3.8 × 10− 10 |
Cd44 | CD44 antigen | 1.1 | 4.7 × 10− 2 | 1.2 | 8.9 × 10− 3 | 3.0 | 6.3 × 10− 11 |
Cxcl10 | Chemokine (C-X-C motif) ligand 10 | 2.4 | 2.1 × 10− 3 | 4.0 | 1.0 × 10− 5 | 4.4 | 4.1 × 10− 6 |
Gfap | Glial fibrillary acidic protein | 1.4 | 3.6 × 10− 2 | 3.3 | 5.5 × 10− 6 | 12.0 | 6.1 × 10− 11 |
Gfap | Splice variant id MSTRG.4106 | 1.2 | 8.5 × 10− 3 | 1.5 | 3.6 × 10− 3 | 4.3 | 1.7 × 10− 8 |
Gfap | Splice variant id MSTRG.4107 | 1.0 | 6.1 × 10− 1 | 1.1 | 1.4 × 10− 1 | 1.9 | 5.0 × 10− 6 |
Hspb1 | Heat shock protein 1 | 0.9 | 2.4 × 10− 1 | 1.1 | 6.6 × 10− 1 | 3.3 | 4.1 × 10− 7 |
Lcn2 | Lipocalin 2 | 1.0 | 7.1 × 10− 1 | 1.2 | 1.8 × 10− 1 | 4.9 | 6.9 × 10− 9 |
Osmr | Oncostatin M receptor | 1.1 | 2.2 × 10− 1 | 1.2 | 5.4 × 10− 2 | 3.6 | 6.1 × 10− 7 |
Serpina3n/3f/3 m | Serine (or cysteine) peptidase inhibitor, clade A, member 3 N /3F/ 3 M | 1.3 | 6.2 × 10− 2 | 2.9 | 5.1 × 10− 6 | 12.3 | 8.3 × 10− 11 |
Timp1 | Tissue inhibitor of metalloproteinase 1 | 1.2 | 2.6 × 10− 1 | 1.2 | 2.7 × 10− 2 | 2.4 | 9.8 × 10− 7 |
Vim | Vimentin | 0.8 | 1.1 × 10− 1 | 1.2 | 2.0 × 10− 1 | 4.3 | 2.8 × 10− 7 |
A1 | |||||||
A2m | Alpha-2-macroglobulin | 1.2 | 3.5 × 10− 2 | 1.4 | 1.6 × 10− 2 | 4.8 | 1.1 × 10− 9 |
B2m | Beta-2 microglobulin | 1.2 | 4.6 × 10− 1 | 2.2 | 9.7 × 10− 4 | 3.7 | 1.9 × 10− 6 |
C3 | Complement component 3 | 0.9 | 4.2 × 10− 1 | 1.2 | 3.3 × 10− 2 | 4.2 | 2.2 × 10− 9 |
C4b | Complement component 4B (Chido blood group) | 1.5 | 4.9 × 10− 4 | 2.8 | 4.2 × 10− 7 | 7.4 | 1.3 × 10− 13 |
Chil1 (Chi3l1) | Chitinase-Like 1 (Chitinase 3-Like 1) | 1.2 | 5.2 × 10− 2 | 1.6 | 4.3 × 10− 4 | 2.5 | 3.1 × 10− 8 |
Fbln5 | Fibulin 5 | 0.9 | 3.6 × 10− 3 | 1.0 | 8.3 × 10− 1 | 1.6 | 1.9 × 10− 5 |
Gbp2 | Guanylate binding protein 2 | 1.0 | 6.8 × 10− 1 | 1.4 | 8.0 × 10− 3 | 2.1 | 2.0 × 10− 5 |
Gbp3 | Guanylate binding protein 3 | 1.2 | 2.4 × 10− 1 | 1.5 | 1.5 × 10− 2 | 2.0 | 2.5 × 10− 4 |
Gbp6/10 | Guanylate binding protein 6/10 | 1.1 | 4.4 × 10− 1 | 1.4 | 9.8 × 10− 4 | 1.6 | 6.2 × 10− 5 |
Ggta1 | Glycoprotein galactosyltransferase alpha 1, 3 | 0.9 | 2.1 × 10− 1 | 0.9 | 3.3 × 10− 1 | 1.7 | 4.1 × 10− 3 |
H2-D1 | Histocompatibility 2, D region locus 1 | 1.3 | 2.5 × 10− 2 | 2.3 | 8.3 × 10− 5 | 3.5 | 9.8 × 10− 8 |
H2-T23 | Histocompatibility 2, T region locus 23 | 1.0 | 9.8 × 10− 1 | 1.6 | 3.1 × 10− 4 | 2.0 | 5.3 × 10− 6 |
Ifitm3/6 | Interferon induced transmembrane protein 3/6 | 2.0 | 7.1 × 10− 2 | 2.5 | 7.5 × 10− 3 | 2.7 | 1.9 × 10− 2 |
Igtp | Interferon gamma induced GTPase | 1.1 | 1.6 × 10− 1 | 1.5 | 1.3 × 10− 4 | 1.8 | 2.4 × 10− 6 |
Iigp1 | Interferon inducible GTPase 1 | 1.1 | 7.0 × 10− 1 | 1.3 | 3.7 × 10− 2 | 1.6 | 8.7 × 10− 4 |
Irgm1 | Immunity-related GTPase family M member 1 | 1.2 | 1.7 × 10− 1 | 1.6 | 2.6 × 10− 3 | 2.2 | 5.2 × 10− 6 |
Psmb8 | Proteasome (prosome, macropain) subunit, beta type 8 | 1.1 | 6.3 × 10− 1 | 1.6 | 1.3 × 10− 2 | 2.6 | 2.9 × 10− 5 |
Serping1 | Serine (or cysteine) peptidase inhibitor, clade G, member 1 | 0.8 | 9.5 × 10–2 | 1.3 | 2.7 × 10−2 | 2.1 | 1.0 × 10− 6 |
Slc22a4 | Solute carrier family 22 (organic cation transporter), member 4 | 1.0 | 9.3 × 10–1 | 1.1 | 1.3 × 10−2 | 1.5 | 6.9 × 10−5 |
A2 | |||||||
Anxa2 | Annexin A2 | 0.8 | 8.1 × 10−2 | 1.0 | 9.7 × 10−1 | 1.6 | 1.3 × 10− 4 |
Anxa3 | Annexin A3 | 1.0 | 9.0 × 10−1 | 1.2 | 6.3 × 10− 2 | 2.5 | 2.1 × 10−6 |
Cd14 | CD14 antigen | 1.1 | 4.5 × 10−1 | 1.4 | 1.3 × 10−2 | 2.8 | 9.4 × 10−8 |
Cd109 | CD109 antigen | 1.0 | 7.5 × 10−1 | 1.0 | 5.4 × 10− 1 | 2.1 | 3.5 × 10− 9 |
Emp1 | Epithelial membrane protein 1 | 0.9 | 2.6 × 10−1 | 1.1 | 1.2 × 10− 1 | 1.7 | 6.7 × 10−7 |
Flnc | Filamin C, gamma | 1.1 | 2.9 × 10−1 | 1.2 | 1.2 × 10−3 | 2.4 | 4.3 × 10−10 |
Hmox1 | Heme oxygenase 1 | 1.1 | 4.9 × 10−1 | 1.5 | 6.8 × 10−4 | 2.7 | 1.3 × 10−7 |
Icam1/4 | Intercellular adhesion molecule 1/4 | 1.0 | 6.1 × 10−1 | 1.2 | 3.2 × 10−4 | 1.7 | 1.6 × 10−8 |
Lgals3 | Lectin, galactose binding, soluble 3 | 1.0 | 8.6 × 10−1 | 1.3 | 9.7 × 10−3 | 4.0 | 8.4 × 10−7 |
Sbno2 | Strawberry notch homolog 2 | 1.2 | 5.1 × 10−2 | 1.2 | 2.6 × 10− 2 | 2.0 | 4.4 × 10−7 |
S1pr3 | Sphingosine-1-phosphate receptor 3 | 1.3 | 2.0 × 10−1 | 1.5 | 1.5 × 10−2 | 4.1 | 8.4 × 10−7 |
Tgm1 | Transglutaminase 1, K polypeptide | 1.1 | 4.5 × 10−3 | 1.1 | 1.2 × 10−2 | 3.2 | 4.2 × 10−8 |
Tnfrsf12a | Tumor necrosis factor receptor superfamily, member 12a | 1.2 | 1.6 × 10−1 | 1.3 | 3.2 × 10− 1 | 2.1 | 1.5 × 10−5 |