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Table 1 Analysis of Pan, A1, and A2 astrocyte signature gene expression by RNA-seq comparing RML prion-infected mice to uninfected mice

From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Gene Description 80 dpia 100 dpi ~ 157c dpi
FCb P value FC P value FC P value
Pan
Aspg Asparaginase 1.1 4.7 × 10− 2 1.4 7.2 × 10− 4 3.1 3.8 × 10− 10
Cd44 CD44 antigen 1.1 4.7 × 10− 2 1.2 8.9 × 10− 3 3.0 6.3 × 10− 11
Cxcl10 Chemokine (C-X-C motif) ligand 10 2.4 2.1 × 10− 3 4.0 1.0 × 10− 5 4.4 4.1 × 10− 6
Gfap Glial fibrillary acidic protein 1.4 3.6 × 10− 2 3.3 5.5 × 10− 6 12.0 6.1 × 10− 11
Gfap Splice variant id MSTRG.4106 1.2 8.5 × 10− 3 1.5 3.6 × 10− 3 4.3 1.7 × 10− 8
Gfap Splice variant id MSTRG.4107 1.0 6.1 × 10− 1 1.1 1.4 × 10− 1 1.9 5.0 × 10− 6
Hspb1 Heat shock protein 1 0.9 2.4 × 10− 1 1.1 6.6 × 10− 1 3.3 4.1 × 10− 7
Lcn2 Lipocalin 2 1.0 7.1 × 10− 1 1.2 1.8 × 10− 1 4.9 6.9 × 10− 9
Osmr Oncostatin M receptor 1.1 2.2 × 10− 1 1.2 5.4 × 10− 2 3.6 6.1 × 10− 7
Serpina3n/3f/3 m Serine (or cysteine) peptidase inhibitor, clade A, member 3 N /3F/ 3 M 1.3 6.2 × 10− 2 2.9 5.1 × 10− 6 12.3 8.3 × 10− 11
Timp1 Tissue inhibitor of metalloproteinase 1 1.2 2.6 × 10− 1 1.2 2.7 × 10− 2 2.4 9.8 × 10− 7
Vim Vimentin 0.8 1.1 × 10− 1 1.2 2.0 × 10− 1 4.3 2.8 × 10− 7
A1
A2m Alpha-2-macroglobulin 1.2 3.5 × 10− 2 1.4 1.6 × 10− 2 4.8 1.1 × 10− 9
B2m Beta-2 microglobulin 1.2 4.6 × 10− 1 2.2 9.7 × 10− 4 3.7 1.9 × 10− 6
C3 Complement component 3 0.9 4.2 × 10− 1 1.2 3.3 × 10− 2 4.2 2.2 × 10− 9
C4b Complement component 4B (Chido blood group) 1.5 4.9 × 10− 4 2.8 4.2 × 10− 7 7.4 1.3 × 10− 13
Chil1 (Chi3l1) Chitinase-Like 1 (Chitinase 3-Like 1) 1.2 5.2 × 10− 2 1.6 4.3 × 10− 4 2.5 3.1 × 10− 8
Fbln5 Fibulin 5 0.9 3.6 × 10− 3 1.0 8.3 × 10− 1 1.6 1.9 × 10− 5
Gbp2 Guanylate binding protein 2 1.0 6.8 × 10− 1 1.4 8.0 × 10− 3 2.1 2.0 × 10− 5
Gbp3 Guanylate binding protein 3 1.2 2.4 × 10− 1 1.5 1.5 × 10− 2 2.0 2.5 × 10− 4
Gbp6/10 Guanylate binding protein 6/10 1.1 4.4 × 10− 1 1.4 9.8 × 10− 4 1.6 6.2 × 10− 5
Ggta1 Glycoprotein galactosyltransferase alpha 1, 3 0.9 2.1 × 10− 1 0.9 3.3 × 10− 1 1.7 4.1 × 10− 3
H2-D1 Histocompatibility 2, D region locus 1 1.3 2.5 × 10− 2 2.3 8.3 × 10− 5 3.5 9.8 × 10− 8
H2-T23 Histocompatibility 2, T region locus 23 1.0 9.8 × 10− 1 1.6 3.1 × 10− 4 2.0 5.3 × 10− 6
Ifitm3/6 Interferon induced transmembrane protein 3/6 2.0 7.1 × 10− 2 2.5 7.5 × 10− 3 2.7 1.9 × 10− 2
Igtp Interferon gamma induced GTPase 1.1 1.6 × 10− 1 1.5 1.3 × 10− 4 1.8 2.4 × 10− 6
Iigp1 Interferon inducible GTPase 1 1.1 7.0 × 10− 1 1.3 3.7 × 10− 2 1.6 8.7 × 10− 4
Irgm1 Immunity-related GTPase family M member 1 1.2 1.7 × 10− 1 1.6 2.6 × 10− 3 2.2 5.2 × 10− 6
Psmb8 Proteasome (prosome, macropain) subunit, beta type 8 1.1 6.3 × 10− 1 1.6 1.3 × 10− 2 2.6 2.9 × 10− 5
Serping1 Serine (or cysteine) peptidase inhibitor, clade G, member 1 0.8 9.5 × 10–2 1.3 2.7 × 10−2 2.1 1.0 × 10− 6
Slc22a4 Solute carrier family 22 (organic cation transporter), member 4 1.0 9.3 × 10–1 1.1 1.3 × 10−2 1.5 6.9 × 10−5
A2
Anxa2 Annexin A2 0.8 8.1 × 10−2 1.0 9.7 × 10−1 1.6 1.3 × 10− 4
Anxa3 Annexin A3 1.0 9.0 × 10−1 1.2 6.3 × 10− 2 2.5 2.1 × 10−6
Cd14 CD14 antigen 1.1 4.5 × 10−1 1.4 1.3 × 10−2 2.8 9.4 × 10−8
Cd109 CD109 antigen 1.0 7.5 × 10−1 1.0 5.4 × 10− 1 2.1 3.5 × 10− 9
Emp1 Epithelial membrane protein 1 0.9 2.6 × 10−1 1.1 1.2 × 10− 1 1.7 6.7 × 10−7
Flnc Filamin C, gamma 1.1 2.9 × 10−1 1.2 1.2 × 10−3 2.4 4.3 × 10−10
Hmox1 Heme oxygenase 1 1.1 4.9 × 10−1 1.5 6.8 × 10−4 2.7 1.3 × 10−7
Icam1/4 Intercellular adhesion molecule 1/4 1.0 6.1 × 10−1 1.2 3.2 × 10−4 1.7 1.6 × 10−8
Lgals3 Lectin, galactose binding, soluble 3 1.0 8.6 × 10−1 1.3 9.7 × 10−3 4.0 8.4 × 10−7
Sbno2 Strawberry notch homolog 2 1.2 5.1 × 10−2 1.2 2.6 × 10− 2 2.0 4.4 × 10−7
S1pr3 Sphingosine-1-phosphate receptor 3 1.3 2.0 × 10−1 1.5 1.5 × 10−2 4.1 8.4 × 10−7
Tgm1 Transglutaminase 1, K polypeptide 1.1 4.5 × 10−3 1.1 1.2 × 10−2 3.2 4.2 × 10−8
Tnfrsf12a Tumor necrosis factor receptor superfamily, member 12a 1.2 1.6 × 10−1 1.3 3.2 × 10− 1 2.1 1.5 × 10−5
  1. Bolded values denote genes increased ≥2.0-fold with p values ≤0.05 (5.0 × 10− 2) in RML-infected mice
  2. Values in italics are increased between 1.5-fold and 1.9-fold with p values ≤0.05 (5.0 × 10− 2) in RML-infected mice
  3. adpi days post inoculation
  4. bFC fold change
  5. c ~ 157 is the average dpi to clinical endpoint for RML-infected mice