Table 3 Analysis of Pan, A1, and A2 astrocyte signature gene expression by RNA-seq comparing prion-infected PLX5622-treated mice (microglia ablated) to similarly infected untreated mice (microglia present)
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Gene | Description | 80 dpia | 100 dpi | Terminalc | |||
|---|---|---|---|---|---|---|---|
FCb | P value | FC | P value | FC | P value | ||
Pan | |||||||
Aspg | Asparaginase | 1.8 | 3.0 × 10− 3 | 2.6 | 1.2 × 10− 6 | 1.5 | 1.9 × 10− 5 |
Cd44 | CD44 antigen | 1.6 | 5.9 × 10− 2 | 4.2 | 6.7 × 10− 6 | 2.0 | 3.2 × 10− 5 |
Gfap | Glial fibrillary acidic protein | 4.2 | 6.8 × 10− 4 | 4.5 | 1.7 × 10− 7 | 1.7 | 4.1 × 10− 6 |
Gfap | Splice variant id MSTRG.4106 | 1.9 | 2.9 × 10− 2 | 3.2 | 1.5 × 10− 6 | 1.9 | 1.1 × 10− 4 |
Gfap | Splice variant id MSTRG.4107 | 1.1 | 4.7 × 10− 1 | 1.8 | 4.8 × 10− 3 | 1.5 | 3.8 × 10− 3 |
Hspb1 | Heat shock protein 1 | 1.6 | 1.2 × 10− 1 | 2.2 | 4.8 × 10− 2 | 2.1 | 2.7 × 10− 2 |
Lcn2 | Lipocalin 2 | 1.5 | 1.4 × 10− 1 | 2.1 | 8.9 × 10− 3 | 2.1 | 3.9 × 10− 3 |
Osmr | Oncostatin M receptor | 1.8 | 3.0 × 10− 2 | 4.2 | 1.1 × 10− 5 | 2.1 | 3.6 × 10− 4 |
Serpina3n/3f/3 m | Serine (or cysteine) peptidase inhibitor, clade A, member 3N /3F/ 3M | 3.5 | 4.1 × 10− 4 | 5.0 | 1.1 × 10− 5 | 2.0 | 1.1 × 10− 4 |
Timp1 | Tissue inhibitor of metalloproteinase 1 | 1.5 | 1.3 × 10− 1 | 2.2 | 1.6 × 10− 5 | 1.8 | 1.3 × 10− 4 |
Vim | Vimentin | 2.6 | 9.8 × 10− 3 | 5.7 | 1.2 × 10− 4 | 3.8 | 1.1 × 10− 6 |
A1 | |||||||
A2m | Alpha-2-macroglobulin | 1.4 | 8.5 × 10− 2 | 3.4 | 6.3 × 10− 5 | 1.9 | 3.3 × 10− 6 |
C3 | Complement component 3 | 1.1 | 2.8 × 10− 1 | 2.4 | 6.6 × 10− 3 | 1.7 | 3.5 × 10− 5 |
C4b | Complement component 4B (Chido blood group) | 2.9 | 1.6 × 10− 4 | 3.0 | 1.2 × 10− 6 | 1.5 | 4.7 × 10− 6 |
Endou | Endonuclease, polyU-specific | 1.3 | 2.8 × 10− 2 | 1.5 | 4.3 × 10− 5 | 1.2 | 2.1 × 10− 2 |
Fbln5 | Fibulin 5 | 1.1 | 2.6 × 10− 2 | 1.2 | 4.0 × 10− 2 | 1.9 | 4.7 × 10− 4 |
Fkbp5 | FK506 binding protein 5 | 0.7 | 6.4 × 10− 2 | 1.0 | 8.3 × 10− 1 | 1.6 | 6.5 × 10− 2 |
Ggta1 | Glycoprotein galactosyltransferase alpha 1, 3 | 1.5 | 3.1 × 10− 2 | 2.4 | 3.2 × 10− 5 | 1.4 | 1.7 × 10− 1 |
Serping1 | Serine (or cysteine) peptidase inhibitor, clade G, member 1 | 1.6 | 7.8 × 10− 2 | 1.6 | 1.9 × 10− 2 | 2.0 | 1.6 × 10− 5 |
Slc22a4 | Solute carrier family 22 (organic cation transporter), member 4 | 1.3 | 3.3 × 10− 3 | 1.5 | 7.3 × 10− 6 | 1.5 | 3.1 × 10− 4 |
Slc39a14 | Solute carrier family 39 (zinc transporter), member 14 | 0.9 | 7.2 × 10− 1 | 1.5 | 5.0 × 10− 2 | 1.2 | 1.8 × 10− 1 |
Sorbs1 | Sorbin and SH3 domain containing 1 | 1.0 | 9.7 × 10− 1 | 1.5 | 4.0 × 10− 3 | 1.3 | 1.1 × 10− 1 |
Sulf2 | Sulfatase 2 | 1.0 | 8.6 × 10− 1 | 1.4 | 6.3 × 10− 3 | 1.7 | 7.2 × 10− 7 |
Tspan4 | Tetraspanin 4 | 1.2 | 4.6 × 10− 1 | 1.3 | 1.6 × 10− 2 | 1.5 | 5.1 × 10− 2 |
A2 | |||||||
Anxa2 | Annexin A2 | 1.3 | 2.8 × 10− 1 | 1.6 | 4.9 × 10− 3 | 1.6 | 1.4 × 10− 4 |
Cd109 | CD109 antigen | 1.2 | 2.1 × 10− 1 | 2.6 | 3.8 × 10− 4 | 2.7 | 4.3 × 10− 8 |
Emp1 | Epithelial membrane protein 1 | 1.2 | 9.1 × 10− 2 | 2.2 | 2.6 × 10− 4 | 1.5 | 7.4 × 10− 2 |
Flnc | Filamin C, gamma | 1.5 | 1.7 × 10− 2 | 2.9 | 1.0 × 10− 5 | 2.1 | 1.7 × 10− 7 |
Gadd45b | Growth arrest and DNA-damage-inducible 45 beta | 1.2 | 5.3 × 10− 1 | 1.5 | 6.7 × 10− 4 | 1.4 | 5.8 × 10− 2 |
Hmox1 | Heme oxygenase 1 | 1.5 | 6.8 × 10− 3 | 1.7 | 6.2 × 10− 4 | 1.2 | 2.0 × 10− 2 |
Lgals3 | Lectin, galactose binding, soluble 3 | 1.3 | 5.4 × 10− 2 | 1.6 | 1.3 × 10− 3 | 1.5 | 7.8 × 10− 2 |
Lif | Leukemia inhibitory factor | 1.1 | 5.8 × 10− 2 | 1.7 | 6.3 × 10− 5 | 1.3 | 8.4 × 10− 5 |
Ptx3 | Pentraxin related gene | 1.2 | 1.2 × 10−1 | 2.0 | 8.2 × 10− 4 | 1.5 | 8.4 × 10− 5 |
S100a10 | S100 calcium binding protein A10 (calpactin) | 1.8 | 1.5 × 10−1 | 2.3 | 9.7 × 10− 3 | 1.5 | 9.3 × 10− 2 |
Sbno2 | Strawberry notch homolog 2 | 1.3 | 1.3 × 10− 2 | 2.0 | 9.5 × 10− 6 | 1.4 | 2.5 × 10− 6 |
S1pr3 | Sphingosine-1-phosphate receptor 3 | 1.5 | 3.9 × 10−1 | 4.1 | 3.0 × 10− 6 | 1.0 | 9.8 × 10− 1 |
Tgm1 | Transglutaminase 1, K polypeptide | 1.5 | 6.8 × 10− 3 | 3.4 | 4.7 × 10− 5 | 1.6 | 3.0 × 10− 4 |
Tm4sf1 | Transmembrane 4 superfamily member 1 | 1.1 | 3.2 × 10−1 | 1.7 | 1.8 × 10− 3 | 1.7 | 2.1 × 10− 5 |
Tnfrsf12a | Tumor necrosis factor receptor superfamily, member 12a | 1.3 | 2.3 × 10−1 | 2.1 | 5.3 × 10−3 | 1.8 | 3.1 × 10− 3 |