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Table 4 Expression changes of microglial effectors in the brain that affect the A1-reactive astrocyte phenotype in RML-infected mice relative to Uninfected mice

From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Gene 80 dpia 100 dpi ~ 157c dpi
FCb P value FC P value FC P value
Tnf 1.08 4.0 × 10− 2 1.12 2.0 × 10− 4 1.39 6.6 × 10− 5
Il1a 1.02 6.5 × 10− 1 1.14 1.2 × 10− 2 1.45 3.5 × 10− 5
C1qa 1.22 2.7 × 10− 1 2.17 1.1 × 10− 3 5.62 9.0 × 10− 6
C1qb 1.24 4.6 × 10− 1 2.71 7.8 × 10− 3 4.60 1.5 × 10− 5
C1qc 0.71 5.6 × 10− 1 1.12 7.7 × 10− 1 5.81 2.8 × 10− 3
Tfgb1 1.13 1.8 × 10− 1 1.56 1.1 × 10− 3 2.73 1.6 × 10− 8
Fgf2 1.03 7.5 × 10− 1 0.98 8.4 × 10− 1 0.88 3.1 × 10− 1
  1. Bolded values denote genes increased ≥2.0-fold with p values ≤0.05 (5.0 × 10− 2) in RML-infected mice relative to Uninfected mice
  2. Values in italics are increased between 1.5-fold and 1.9-fold with p values ≤0.05 (5.0 × 10− 2 in RML-infected mice relative to Uninfected mice
  3. adpi days post inoculation
  4. bFC fold change
  5. c ~ 157 is the average dpi to clinical endpoint for RML-infected mice