Table 4 Expression changes of microglial effectors in the brain that affect the A1-reactive astrocyte phenotype in RML-infected mice relative to Uninfected mice
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Gene | 80 dpia | 100 dpi | ~ 157c dpi | |||
|---|---|---|---|---|---|---|
FCb | P value | FC | P value | FC | P value | |
Tnf | 1.08 | 4.0 × 10− 2 | 1.12 | 2.0 × 10− 4 | 1.39 | 6.6 × 10− 5 |
Il1a | 1.02 | 6.5 × 10− 1 | 1.14 | 1.2 × 10− 2 | 1.45 | 3.5 × 10− 5 |
C1qa | 1.22 | 2.7 × 10− 1 | 2.17 | 1.1 × 10− 3 | 5.62 | 9.0 × 10− 6 |
C1qb | 1.24 | 4.6 × 10− 1 | 2.71 | 7.8 × 10− 3 | 4.60 | 1.5 × 10− 5 |
C1qc | 0.71 | 5.6 × 10− 1 | 1.12 | 7.7 × 10− 1 | 5.81 | 2.8 × 10− 3 |
Tfgb1 | 1.13 | 1.8 × 10− 1 | 1.56 | 1.1 × 10− 3 | 2.73 | 1.6 × 10− 8 |
Fgf2 | 1.03 | 7.5 × 10− 1 | 0.98 | 8.4 × 10− 1 | 0.88 | 3.1 × 10− 1 |