Table 5 Expression changes of microglial effectors in the brain that affect the A1-reactive astrocyte phenotype in PLX5622 treatment of RML-infected mice relative to Untreated RML-infected mice
From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
Gene | 80 dpia | 100 dpi | ~ 127c dpi | |||
|---|---|---|---|---|---|---|
FCb | P value | FC | P value | FC | P value | |
Tnf | −1.05 | 1.4 × 10− 1 | −1.07 | 1.7 × 10− 2 | 1.11 | 3.7 × 10− 1 |
Il1a | − 1.18 | 7.0 × 10− 4 | − 1.17 | 3.7 × 10− 3 | − 1.17 | 2.4 × 10− 2 |
C1qa | − 2.26 | 6.7 × 10− 2 | − 1.76 | 1.4 × 10− 2 | −1.37 | 3.1 × 10− 1 |
C1qb | −2.93 | 4.6 × 10− 3 | −2.53 | 5.5 × 10− 3 | − 1.59 | 8.0 × 10− 2 |
C1qc | −1.59 | 5.3 × 10− 1 | −1.95 | 1.3 × 10− 1 | −1.86 | 1.6 × 10− 1 |
Tgfb1 | − 1.50 | 5.8 × 10− 2 | − 1.71 | 7.0 × 10− 4 | −1.39 | 1.0 × 10− 1 |
Fgf2 | 1.09 | 4.7 × 10− 1 | 1.37 | 2.9 × 10− 3 | 1.13 | 3.1 × 10− 1 |