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Table 5 Expression changes of microglial effectors in the brain that affect the A1-reactive astrocyte phenotype in PLX5622 treatment of RML-infected mice relative to Untreated RML-infected mice

From: RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Gene 80 dpia 100 dpi ~ 127c dpi
FCb P value FC P value FC P value
Tnf −1.05 1.4 × 10− 1 −1.07 1.7 × 10− 2 1.11 3.7 × 10− 1
Il1a − 1.18 7.0 × 10− 4 − 1.17 3.7 × 10− 3 − 1.17 2.4 × 10− 2
C1qa − 2.26 6.7 × 10− 2 − 1.76 1.4 × 10− 2 −1.37 3.1 × 10− 1
C1qb −2.93 4.6 × 10− 3 −2.53 5.5 × 10− 3 − 1.59 8.0 × 10− 2
C1qc −1.59 5.3 × 10− 1 −1.95 1.3 × 10− 1 −1.86 1.6 × 10− 1
Tgfb1 − 1.50 5.8 × 10− 2 − 1.71 7.0 × 10− 4 −1.39 1.0 × 10− 1
Fgf2 1.09 4.7 × 10− 1 1.37 2.9 × 10− 3 1.13 3.1 × 10− 1
  1. Bolded values denote genes decreased ≥2.0-fold with p values ≤0.05 (5.0 × 10− 2) in infected PX5622-treated mice relative to infected untreated mice
  2. Values in italics are decreased between 1.5-fold and 1.9-fold with p values ≤0.05 (5.0 × 10− 2) in infected PX5622-treated mice relative to infected untreated mice
  3. adpi days post inoculation
  4. bFC fold change
  5. c ~ 127 dpi is the average dpi to clinical endpoint for infected PLX5622-treated mice