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Table 2 Autism Diagnostic Interview-Revised (ADI-R) of the patient at the age of 41.8 months

From: Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism

Domain

Score

Qualitative Abnormalities in Reciprocal Social Interaction (RSD)

 Failure to use nonverbal communication to regulate social interaction (A1)

6

 Failure to develop peer relationships (A2)

4

 Lack of shared enjoyment (A3)

6

 Lack of socioemotional reciprocity (A4)

8

 Subtotal (Cut-off)

24 (10)

Qualitative Impairments in Communication and Language (COM)

 Lack of, or delay in, spoken language and failure to compensate through gesture (B1)

8

 Lack of varied spontaneous make-believe or social imitative play (B4)

6

 Subtotal (Cut-off)

14 (7)

Restricted, Repetitive, and Stereotyped Behaviors and interests (RRB)

 

 Encompassing preoccupations or circumscribed pattern of interest (C1)

0

 Apparently Compulsive Adherence to Nonfunctional Routines or Rituals (C2)

0

 Stereotyped and repetitive motor mannerisms (C3)

2

 Preoccupation with part of objects or nonfunctional elements of material (C4)

2

 Subtotal (Cut-off)

4 (3)

Abnormality of development evident at or before 36 months (Cutoff)

5 (1)

Total (Cut-off)

47 (21)

  1. COM qualitative abnormalities in communication, RRB restricted and repetitive Behavior; RSI qualitative abnormalities in reciprocal social interaction