Skip to main content
Fig. 4 | Molecular Brain

Fig. 4

From: 1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Fig. 4

1-O-acetylgeopyxin A inhibits TTX-sensitive Na + currents in dorsal root ganglion (DRG) neurons. a,c Representative traces of TTX-sensitive (a) and TTX-resistant (b) Na+ currents from DRG sensory neurons treated with 0.1% DMSO (control) or 20 μM 1-O-acetylgeopyxin A. b, d Summary (± SEM) of the peak TTX-sensitive (b) or TTX-resistant (d) Na+ current density (mean ± SEM) from DRG neurons treated as indicated. TTX-sensitive and TTX-resistant fractions were calculated as described in the Methods section. Asterisk indicate statistical significance compared with cells treated with 0.1% DMSO (*P < 0.05, unpaired two-tailed Student’s t test, n = 15–18 per condition, Mann−Whitney test)

Back to article page

Molecular Brain

ISSN: 1756-6606