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Fig. 5 | Molecular Brain

Fig. 5

From: 1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Fig. 5

1-O-acetylgeopyxin A inhibits excitability in dorsal root ganglion (DRG) neurons. a Representative recordings in response to various steps of depolarizing current to measure rheobase (i.e. current required for eliciting the first action potential (AP)) in sensory neurons incubated with DMSO or 20 μM 1-O-acetylgeopyxin A. Summary of the measured mean (± SEM) rheobase (b) and AP spike height (in millivolts, mV) (c) in indicated conditions (n = 8–12 as indicated; (*P = 0.0085, unpaired two-tailed Student’s t test). d Representative traces of action potentials displayed by DRG neurons in culture after incubation with DMSO or 20 μM 1-O-acetylgeopyxin A in response to current injections of 1x or 2x rheobase. e Bar graphs of mean frequency of APs in response to current injections of 1x, 2x, or 3x rheobase. (*P < 0.05, one-way ANOVA with Dunnett’s post hoc test)

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Molecular Brain

ISSN: 1756-6606