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Fig. 4 | Molecular Brain

Fig. 4

From: A two-compartment model of synaptic computation and plasticity

Fig. 4

The presynaptic filter locally sharpens the tuning curve of the input neurone. a Example tuning curve of an orientation-selective neurone in the primary visual cortex. The single-compartment model leads to a postsynaptic amplification of the orientation tuning curve transmitted by the presynaptic neurone. This amplification uniformly impacts all presynaptic firing frequencies, which leads to the transmission of potentially irrelevant stimuli, for example when the tuning curve of the postsynaptic neurone is sharper (see mismatch between tuning curve of the input (dashed line) and tuning curve of the postsynaptic neurone). b In the two-compartment model, the same tuning curve is first sharpened due to the presynaptic frequency filter. For example, by using a low Pr synapse, high frequency presynaptic firing can be preferentially transmitted, enabling selective transmission of only relevant stimuli. The postsynaptic terminal can then selectively amplify this input. The two-compartment model can therefore optimize the signal-to-noise ratio of synaptic transmission

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