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Fig. 6 | Molecular Brain

Fig. 6

From: Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux

Fig. 6

PD98059 rescues spine density and autophagy disruption in PPA-treated hippocampal neurons a Top shows representative pyramidal neurons transfected with PLV-GFP and treated with PPA (100 μM) and PD98059 (10 μM) for 72 h. Bottom shows high magnification of representative secondary dendrites. Scale bar of top panel is 20 μm; scale bar of bottom panel is 1 μm. b Bar graph showing mean ± SEM for dendritic spine numbers of the representative groups (n = 50). c Top shows representative TEM images in PPA (100 μM) and PD98059 (10 μM) for 72 h (white arrow is autolysosome). Bottom shows high magnification of representative images of autolysosome. d Quantification of autolysosome number per cell (n = 10). Bar graph showing mean ± SEM of the representative groups. *p < 0.05, **p < 0.01, ****p < 0.0001

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