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Table 1 Drp1 protein and mRNA expression in different brain regions and spinal cord

From: Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system

Abbreviation Regions Intensity
protein mRNA
CTX cerebral cortex   
 RSPv1 retrosplenial area, ventral part, layer 1 +
 RSPv2/3 retrosplenial area, ventral part, layer 2/3 + ++++
 RSPv5 retrosplenial area, ventral part, layer 5 ++ +++
 RSPv6 retrosplenial area, ventral part, layer 6 + +++
 RSPd1 retrosplenial area, dorsal part, layer 1 +
 RSPd2/3 retrosplenial area, dorsal part, layer 2/3 + +++
 RSPd5 retrosplenial area, dorsal part, layer 5 ++ +++
 RSPd6 retrosplenial area, dorsal part, layer 6 + +++
 PTLp1 posterior parietal association areas, layer 1 +
 PTLp2/3 posterior parietal association areas, layer 2/3 + +++
 PTLp4 posterior parietal association areas, layer 4 + +++
 PTLp5 posterior parietal association areas, layer 5 ++ +++
 PTLp6 posterior parietal association areas, layer 6 + +++
 AUD1 auditory area, layer 1 +
 AUD2/3 auditory area, layer 2/3 + ++++
 AUD4 auditory area, layer 4 + +++
 AUD5 auditory area, layer 5 ++ +++
 AUD6 auditory area, layer 6 + +++
 TEa1 temporal association areas, layer 1 +
 TEa2/3 temporal association areas, layer 2/3 + ++++
 TEa4 temporal association areas, layer 4 + +++
 TEa5 temporal association areas, layer 5 ++ +++
 TEa6 temporal association areas, layer 6 + +++
 PIR1 piriform area, molecular layer 1 +
 PIR2 piriform area, molecular layer 2 + ++++
 PIR3 piriform area, polymorph layer 3 + ++
HIP hippocampal region   
 CA1so field CA1, stratum oriens + +
 CA1sp field CA1, pyramidal layer + ++++
 CA1sr field CA1, stratum radiatum + +
 CA1slm field CA1, stratum lacunosum-moleculare + ++
 DG-mo molecule layer of dentate gyrus + +
 DG-sg granular cell layer of dentate gyrus + ++++
 DG-po polymorphic layer of dentate gyrus ++ +++
TH thalamus   
 VPL ventral posterolateral nucleus of the thalamus + +++
 VPM ventral posteromedial nucleus of the thalamus + +++
 LGd dorsal part of the lateral geniculate complex +++ +++
 IGL intergeniculate leaflet of the lateral geniculate complex ++ +++
 LGv ventral part of the lateral geniculate complex +++ +++
 PO posterior complex of the thalamus + +++
 PF parafascicular nucleus N/A +++
MB midbrain   
 PAG periaqueductal gray ++ +++
 MRN midbrain reticular nucleus N/A ++
 IC inferior colliculus N/A +++
 DR dorsal nucleus raphe N/A ++++
P pons   
 PB parabrachial nucleus ++++ ++++
 LC locus ceruleus +++ ++++
 B Barrington’s nucleus +++ ++++
 PCG pontine central gray + +++
MY medulla   
 CN cochlear nuclei ++++ +++
 VCO ventral cochlear nucleus ++++ +++
 DCO dorsal cochlear nucleus ++++ +++
 CNlam granular lamina of the cochlear nuclei +++ +++
 PARN parvicellular reticular nucleus + ++
 VII facial motor nucleus ++++ +++
 SPVI spinal nucleus of the trigeminal, interpolar part +++ N/A
 NTS nucleus of solitary tract ++ N/A
 ECU external cuneate nucleus ++++ N/A
 PAS parasolitary nucleus + N/A
 MDRN medullary reticular nucleus +++ N/A
 SPVO spinal nucleus of the trigeminal, oral part N/A ++
 IRN intermediate reticular nucleus N/A ++
 sptV spinal tract of the trigeminal nerve N/A +
 SPIV spinal vestibular nucleus ++ N/A
CB cerebellum   
 SIMgr simple lobule, granular layer ++++
 SIMpu simple lobule, Purkinje layer ++++ ++++
 SIMmo simple lobule, molecular layer + ++
 FLgr flocculus, granular layer ++++
 FLmo flocculus, molecular layer + ++
 IP interposed nucleus ++ +++
 SUV superior vestibular nucleus N/A N/A
 MGv medial geniculate complex, ventral part N/A N/A
 MEV midbrain trigeminal nucleus N/A N/A
fiber tracts
 cing cingulum bundle +
 cc corpus callosum +
 alv alveus +
 df dorsal fornix +
 fr fasciculus retroflexus N/A +
 scp superior cerebelar peduncles N/A +
 icp inferior cerebellar peduncle N/A +
 sctv ventral spinocerebellar tract N/A +
 rust rubrospinal tract N/A +
VS ventricular systems   
 V4 fourth ventricle N/A
 V4r lateral recess N/A ++++
 AQ cerebral aqueduct N/A
spinal cord
 Lamina I   + ++++
 Lamina II   + +++
 Lamina III   + +++
 Lamina IV   + +++
 Lamina V   + +++
 Lamina VI   + +++
 Lamina VII   ++ +++
 Lamina VIII   ++ +++
 Lamina IX   ++ +++
 Lamina X   ++ +++
  1. Drp1 expression was determined based on the labeling intensity, which was classified as no signal (−), low signal (+), moderate signal (++), high signal (+++), and strong signal (++++). “N/A” represents this region was not observed or counted