Fig. 3
Loss of PTPδ does not induce abnormal organization of synapse structures in cultured hippocampal neurons. a, Representative electron micrographs of cultured hippocampal neurons from PTPδf/f mice infected with lentiviruses expressing ΔCre (control) or Cre. b, c, PTPδ deletion has no effect on the length of synaptic membranes. Cumulative distributions of the lengths of AZ (b) and PSD (c) for the indicated genotypes. Data are means ± SEMs (n denotes the number of analyzed neurons; ΔCre, n = 88; Cre, n = 105; Mann Whitney U-test). d–f, Total number of vesicles per bouton (d), membrane-proximal vesicles (e), and membrane-tethered vesicles (f) in control and PTPδ-deficient synapses. Data are means ± SEMs (n denotes the number of analyzed neurons; ΔCre, n = 88; Cre, n = 105; Mann Whitney U-test)