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Fig. 2 | Molecular Brain

Fig. 2

From: Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients

Fig. 2

The rs12411216 SNP affects GBA expression. a Positions in the genome of the knocked out DHS and the replaced SNP. b, c mRNA levels of GBA and SNCA. d GBA enzymatic activity (normalized to the control) measured using lysosome-enriched fractions in control SH-SY5Y cells, DHS-knockout SH-SY5Y cells and SNP-replaced SH-SY5Y cells (n = 6). e–h Western blotting results before and after DHS knockout and SNP replacement. *p < 0.05; ** p < 0.01; ***p < 0.001. Data are expressed as means ± SEMs. K-DHS: DHS-knockout cells; T-SNP: SNP-replaced cells

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Molecular Brain

ISSN: 1756-6606