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Fig. 6 | Molecular Brain

Fig. 6

From: Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum

Fig. 6

Time-dependent behavior of CD45-positive cells in the ATP-injured cortex and striatum. a Sections were obtained from the cortex and striatum at the indicated times post-ATP injection, and stained for CD45. CD45-positive cells were not detected in the intact brain, but appeared at the boundary of injury sites 1 d post-injury (arrows), and gradually filled the injury core at 3–30 d (arrows). Like Iba-1–positive cells, CD45-positive cells were more densely packed in areas surrounding the damage sites, and near the corpus callosum in the damaged cortex and striatum. b CD45 and MMP-13 mRNA levels were analyzed by RT-qPCR at the indicated times after ATP injection. Values are means ± SEMs of at least 3 animals (*, p < 0.05, **, p < 0.001; two-way ANOVA, CD45: F(4, 40) = 7.336, p = 0.0002, interaction; F(1.949, 19.49) = 19.87, p < 0.0001, time; F (1, 10)=26.01, p = 0.0005, region; F(10, 40) = 1.046, p = 0.4245, subjects; MMP-13: F (4, 32)=18.23, p < 0.0001, interaction; F(1.044, 8.349) = 57.95, p < 0.0001, time; F (1, 8)=16.19, p = 0.0038, region; F (8, 32)=1.489, p = 0.2002, subjects)

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