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Fig. 8 | Molecular Brain

Fig. 8

From: Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum

Fig. 8

Avastin attenuates astrogliosis and blood vessel formation in the injured cortex. a, c Cortical sections were obtained from mice in which Avastin or PBS was infused into the ventricle 14 d post-ATP injection. GFAP and CoL1A1 were visualized with Alexa-488 and Alexa-594 conjugated secondary antibodies (a) or biotinylated secondary antibodies and DAB-based color reaction (c). b Relative fluorescence intensity of GFAP and CoL1A1 were measured using ZEN software and plotted. Values are means ± SEMs for animals treated with saline (n = 4) or Avastin (n = 3) (*, p < 0.05; Student’s t-test, GFAP: F (3, 4)=7.983, p = 0.0017; CoL1A1: F (3, 5)=1.638, p = 0.0185)

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Molecular Brain

ISSN: 1756-6606