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Fig. 6 | Molecular Brain

Fig. 6

From: Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development

Fig. 6

HDAC6 and SIRT2 regulate neuronal migration through cortactin deacetylation in vivo. HDAC6 or SIRT2 single knockdown neurons properly migrated into pial surface. However, HDAC6 and SIRT2 double KD neurons and cortactin acetylation mimetic form expressing neurons did not migrate to the pial surface. a HDAC6 and SIRT2 double knockdown neurons did not migrate into cortical plate properly. Neurons overexpressing acetylation mimetic form of cortactin had a defect in radial migration. Scale bar, 50 μm (b) Graphs represent the percentage of transfected cells in the cortical layer. *p < 0.05, **p < 0.01, ***p < 0.001 by two-tailed Student’s t-test. Error bar means ± S.D. in all graphs

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